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Metastatic breast cancer: Anyone else?
Breast Cancer | Last Active: Mar 12 3:44pm | Replies (213)Comment receiving replies
I received an addendum to my path report this morning stating the cancer in lymph node was weakly and partially positive for ER beta1 and negative for androgen receptor. Can someone shed some light on this for meaning? I know it means most likely coming from original breast cancer but what is beta1 and androgen receptor?
Thanks for any insight.
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This appears to be a more specific version of ER+ and the androgen receptor seems to be related to the progesterone receptor. I am not a doctor, so ask your doc. But this seems to mean you are weakly ER+ and PR-.
from Google: Estrogen receptor beta (ERβ) also known as NR3A2 (nuclear receptor subfamily 3, group A, member 2) is one of two main types of estrogen receptor—a nuclear receptor which is activated by the sex hormone estrogen.[5]
and
The androgen receptor (AR), also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a type of nuclear receptor[9] that is activated by binding any of the androgenic hormones, including testosterone and dihydrotestosterone[10] in the cytoplasm and then translocating into the nucleus. The androgen receptor is most closely related to the progesterone receptor, and progestins in higher dosages can block the androgen receptor