I had been on prednisone for over a year and half, but gradually tapered off last spring/early summer. The fatigue hit me hard, and there were days at work where I was fighting to keep my eyes open. I have also been having major issues with my asthma. My doctor started me on hydroxychloroqine before I tapered off of the prednisone, but when I hit that 5 or 6 mg dose, it felt like it wasn't doing anything. My Rhematologist explained that I was dealing with residual pain from being on the prednisone for so long. Apparently, it takes at least 6 to 9 months and maybe longer for your body to adjust after being on Prednisone because it needs to re-learn how to produce adrenaline and other body chemicals. She tried adding Celecoxib, but it did absolutely nothing for me, so we stopped. Then we slowed my taper a bit and she added Diflunisal and Tylenol Arthritis to the mix. This helped a lot and I have now gotten to the point that I no longer need the Tylenol. I also stopped taking my nightly dose of Diflunisal, though I still feel it a bit in the morning until I take my morning dose. I should also note that I am an MGUS patient (the earliest stage of multiple myeloma) and during my bloodwork, it was discovered that my ferritin (stored iron) was low, even though the iron in my blood was normal. I now receive ferritin infusions which has helped not only my fatigue and anemia, but also slightly relieved my pain and helped with my breathing. I don't know if any of this information can help anyone, but I hope it will. God bless.