My adult daughter is in the top 2% of chronic migraines. She has had multiple treatments - drugs, surgeries, biofeedback, etc. They put her on this injection with her monthly botox and it has been a game changer. Granted, she still has some oral meds. I can only remember the muscle relaxers and something to help her sleep and one other. Sounds like a lot but she has mild migraines daily where she was having huge ones - debilitating. This injection has pretty much taken her off most oral meds and she is thrilled. The most difficult part is getting after the insurance to keep paying for it. She has good insurance but like all insurances, they are never trilled to pay for an expensive Rx. They also pay for the botox.