Colleen - many thanks for your very helpful response. I did not participate in the trial but my oncologist was so impressed with the initial trial results he gave me similar treatment. Again thanks for sending me the link to the latest update on the trial. I will be discussing this with my oncologist in early December after my next scan and pathology tests. I suspect that this will be the time we will be discussing further treatment as the scans may show results given the rapid rise in PSA.