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High or Fluctuating Chromogranin A Level: What does it mean?
Neuroendocrine Tumors (NETs) | Last Active: Jun 18 3:39pm | Replies (184)Comment receiving replies
I have been operated for pancreatic tumor whipple surgery in April 2022. One month after surgery my CGA level was 530. Later on in July 22,when tested the CGA level increased to 2250. When it was tested again in October 22 the level increased to 3300. The dota pet scan and MRI of upper abdomen was also done again in October 22 but no abnormal DOTANOC uptake in surgical bed or anywhere else in the body surveyed. Then what is the reason ,that CGA level is increasing day by day? Is there any medication to restrict/decrease it to normal level.
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Hi @casualsuman and @sanjaykumar1. It looks like you may have created 2 accounts - Perhaps son and father?
Abnormal and increasing levels of CgA can be alarming. It is important to talk to your doctor about these results. Fellow patients on a forum like this cannot determine the cause of the rising CgA levels. To know if the levels are related to the neuroendocrine tumors, your oncologist will order further testing.
Although CgA is the most widely used tumor marker in patients with a suspected or confirmed neuroendocrine tumor, CgA testing has limitations.
I think you'll find the information from this website helpful.
- Chromogranin A https://www.testing.com/tests/chromogranin/
Here's an excerpt:
"CgA levels can be elevated in a range of health conditions other than neuroendocrine tumors. For example, CgA levels may increase in people with irritable bowel disease, chronic hepatitis, liver failure, inflammatory diseases, and renal failure. Several medications can also cause an elevation in CgA levels.
As a result, CgA testing for neuroendocrine tumors may produce an elevated result that shows signs of a NET when a person does not actually have this kind of tumor.
Multiple laboratory tests are available to measure the amount of chromogranin A in the blood. Results can vary depending on the test that is used. If CgA levels are being monitored over time, it is important that the same test method be used each time."