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Kevzara (sarilumab) to treat PMR

Polymyalgia Rheumatica (PMR) | Last Active: Aug 24 6:34am | Replies (162)

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@johnbishop

Hi @hfoster, You mentioned being diagnosed with PMR in June 2022 which is not too long being on prednisone. Tapering down to 8 mg prednisone after only 5 or so months seems pretty fast depending on what dosage you started at. I started at 20 mg for both of my occurrences of PMR . First time took 3-1/2 years to taper off, the second time 1-1/2 years but I made some lifestyle changes to help with the inflammation, more exercise and improved diet.

@martiesowers and @lmoross have posted about Kevzara in another discussion and may have some experience or thoughts to share with you. Also, I found this recent study on the drug along with the link to the clinical trial:
-- Sarilumab shows treatment promise in relapsing polymyalgia rheumatica:
https://rheumatology.medicinematters.com/eular-2022/polymyalgia-rheumatica-/il-6-inhibitor-sarilumab-saphyr-study/23127802.
-- Evaluation of the Efficacy and Safety of Sarilumab in Patients With Polymyalgia Rheumatica:
https://clinicaltrials.gov/ct2/show/NCT03600818

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Replies to "Hi @hfoster, You mentioned being diagnosed with PMR in June 2022 which is not too long..."

I was diagnosed with PMR at age 50. I woke up one day and suddenly could not lift my arms and could not walk up stairs without gripping the rail and pulling myself.
The good news: My PMR was treated with prednisone. I took it for two years and then weaned myself off it. PMR has never returned. I am now 75.