I use MSM (3grams) without a problem but I don't take methotrexate. I tried glucosimine and chondroitin for awhile but I am not a good pill taker and it was just too labor intensive to get down. I am on so many anti-inflamatories right now it's no wonder my labs are in normal range. Besides the methyl prednisalone, (8mg) there is sulfasalazine, low dose naltrexone, and the MSM.