I had the biopsy, via the anal canal, also, performed in my Urologist’s office. No real pain, discomfort yes, and I could converse with the Doctor during the procedure. I also had the new non-invasive test, the PSMA test, completely covered by Medicare. Perhaps your Doctor has Nitrous Oxide available; I used that during my Urolift procedure, now moot as my prostate was removed via robotically-assisted laparoscopically prostatectomy. Best of luck, and prayers, to you.