to fala - When you posted - we are all so different - talk about hitting the nail on the head! So true, a med or treatment might help 10 people out of 100. The 90 other people wonder why a certain drug or treatment did not work for them. We with PN have such different causes and such different symptoms. The trial and error as you mention is needed. We all need to find what might give us some degree of relief. There is no one magic pill for a cure. Meanwhile, sharing information is helpful and for now, if each person can find something that helps to improve their life style while living with PN, then that is a step in the right direction. Best to all! Ed