Letrozole and checking estrogen levels
I have been taking Letrozole for 6 months. Is there a test (ideally a test that is sensitive and can indicate if the AI is actually working) that can check my estrogen levels? The only Estradiol test I have had was one that was checked just to confirm "menopausal status" a few months after removal of ovaries. However, this test was not very sensitive as it was not sent to a special lab and the results were received in just a few hours. I would have anticipated a lower number, but my Oncologist indicated that it was not a very sensitive assay. I would just like another potential test option that is more sensitive/comprehensive if possible.
Thank you for any thoughts!
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That is very interesting information. Thank you so much for reaching out. I will look forward to hearing how you are doing in the future and I wish all the best to you!
I had a first annual mammogram, ultrasound and oncologist's physical exam last week and no cancer was detected. Or am, at least at the moment, seemingly cancer-free. I did not take aromatase inhibitors (or chemo or radiation) but did have a low 'risk of recurrence' score on the OncotypeDX test.
I have two friends, also over 60, who had stage 1 tumors removed as lumpectomies who also declined to take aromatase inhibitors after receiving low risk scores on the OncotypeDX. One had cancer 5 years ago and the other 3 years ago. Neither has had a recurrence though only time will show if that cancer-free state holds. But that's true for everyone including those who 'do everything possible' to prevent a recurrence.
According to my breast cancer surgeon, older women are increasingly less likely to take the drugs. Especially if genomics testing suggests a low risk of recurrence. Another factor that plays into the decision for older women, in addition to quality of life and possible commorbitity factors, is the thought that cancers tend to progress more slowly in older women so the whole risk/reward analysis is different.
There are few valuable statistics for this demographic as older women have only relatively recently being routinely screened and early breast cancers identified. So it's an area for breast cancer research to explore and, maybe, new guidelines will be proposed for older women. The NCCN modified its radiation recommendations for certain early stage cancers in women over 70 and likely other 'standard recommendations' are being reviewed.
Thank you!
@eku . Thank you. 💕
I would love to read about revised radiation recommendation for certain early cancers in women over 70. I could not locate that information on NCCN website. Might you direct me to that area? Thank you. 🌸
I would also love to see any data, articles or testimonies on inhibitors for women over 70 years. I too am newly diagnosed IDC and meeting my Oncologist for the first time after my surgery. Sending hugs all along the way and praying blessings for this group. Thank you, Elliej
We need to be clear on what @callalloo is referring to by "early stage" cancers? DCIS? Tiny stage 1A?
@elliej the aromatase inhibitors cut risk by approximately 50%. My score was 8, 10 year recurrence risk 6% with meds so, I was told, approx. 12% without meds. No benefit from chemo (report has a graph), so chemo actually would just be harmful.
Later testing, 5 years out with Breast Cancer Index showed no benefit with extended AI. Both the BCI and Prosigna had me at a higher risk (for years 5-10) than the Oncotype (BCI 5.7% risk with cutoff at 5.1 for high risk, Prosigna 9% (intermediate is 7-14%).
The oncologist printed it from the NCCN website and gave it to me. I find the NCCN hard to use but will try to find the exact page if I get a chance. The NCCN is continually revising the protocols for cancer treatment in an effort to not over-treat or expose patients to other risks unnecessarily.
I m in month 6 with Anastrozole and just had a blood draw and requested that estradiol be included. Result was available within 24 hours and was <15, I guess exact number (measurement) is elusive? Menopause is < 30 . So I’m assuming the aromatase is doing it’s job but will discuss with oncologist. 🌸
I did scour the website and did not find. Greatly appreciated if you do find it. Thank you.