@anjalima thank you so much for your input and I hope you are doing well in your journey! I think that sounds like a good idea trying out an AI just to see if I have any reactions. I also tend to have strong reactions to meds (and allergic reactions). I am 61 and am post-menopausal. I was originally taking HRT meds before being diagnosed with breast cancer (due to extreme hot flashes and feeling sick from menopause symptoms). I am leaning toward trying an AI (my surgeon mentioned letrozole) and foregoing the radiation, unless I can find some more definite data showing risk/benefit. I also need to evaluate based on my Oncotype results, which I have not yet received.