Good morning, @hlp123 I read through a number of studies last night, along with the manufacturer’s site about how long Reclast (zoledronic acid) is effective in the body and were no definitive time frames…without going into the complex scientific data that’s way above my pay grade. 😂

Endocrinology Advisor had this article of the latest studies at the time…in 2014 about 1 dose “Effective for 3 Years in Frail Women With Osteoporosis”. https://www.endocrinologyadvisor.com/home/topics/bone-metabolism/zoledronic-acid-safe-effective-for-3-years-in-frail-women-with-osteoporosis/#:~:text=Zoledronic%20Acid%20Safe%2C%20Effective%20for%203%20Years%20in,Bone%20and%20Mineral%20Research%20%28ASBMR%29%202014%20Annual%20Meeting.

We know it’s given annually for treatment of osteoporosis and every 2 years to prevent it. But the articles didn’t say if the product was still active at the end of that period or if it’s the residual of the bone density left behind while it was active.
Basically, the drug reduces bone cell turnover…meaning it impedes the breakdown of old bone cells and builds new bone. However, that break down and regrowth is a key process in successful bone building. So if someone is having major bone loss, halting it with a product like Reclast can help to stabilize the density.
But that can have impact on extractions and how quickly the bone regenerates in that area. That’s why the doctor will have follow ups to make sure the extraction site is healing properly.
I can’t answer how long you should wait before continuing on with treatment. That can only be answered by your dentist and oral surgeon. But if this current extraction site has no issues then it may signal them that it’s ok to proceed with the remaining extractions.
How are your lower teeth? Are you planning on full mouth dentures?