I am treating bone density with Reclast Infusions. My Rheumatologist and Endocrinologist recommend it over the Prolio. Since Prednisone can cause bone loss it is important to treat the bones for Osteoporosis and low bone density. Both are treatments. Reclast is done once a year for 3 consecutive years. Then if your density is good you are done. I have my third in March so hopefully it worked. Good luck.