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Diagnosed with DCIS: How do I decide on treatment?
Breast Cancer | Last Active: Mar 20 10:00am | Replies (345)Comment receiving replies
The primary tumor can promote metastasis by inducing the creation of a permissive microenvironment in a secondary organ site, termed the pre-metastatic niche (15,16). The alteration of bone health associated with osteoporosis may provide fertile soil for the activation of the metastatic cascade, from the seeding of tumor cells to the activation of indolent micrometastases and finally to the expansion of bone lesions
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256706/
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@lcr2017 I read your link and for me, the most important sentence was the last one: "The suggestion that estrogen deprivation with AIs can favour a ‘bone-related’ risk conditions for developing bone metastases must be considered with caution and surely needs further validations; our next multicenter confirmatory study will try to shed light on this topic."
The idea that aromatase inhibitors encourage metastasis both by creating an environment that encourages it, and by causing osteoporosis that also encourages it, is pretty darn alarming- and will affirm those who decline these meds.
I am going to ask my doctor about this. These issues are a far cry from my original question about whether Prolia and biphosphonates have preventative effects regarding metastasis, as well as having protective effects for bones.