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Diagnosed with DCIS: How do I decide on treatment?
Breast Cancer | Last Active: Mar 20 10:00am | Replies (345)Comment receiving replies
@lcr2017 can you cite that these meds help prevent metastasis? I always thought that too, but researching shows that Prolia and Reclast and similar drugs prevent damage to bones from metastasis, but not metastasis itself. I would love to read anything you have found.
Replies to "@lcr2017 can you cite that these meds help prevent metastasis? I always thought that too, but..."
The primary tumor can promote metastasis by inducing the creation of a permissive microenvironment in a secondary organ site, termed the pre-metastatic niche (15,16). The alteration of bone health associated with osteoporosis may provide fertile soil for the activation of the metastatic cascade, from the seeding of tumor cells to the activation of indolent micrometastases and finally to the expansion of bone lesions
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256706/
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I can’t find the citations (and honestly don’t understand the language), but my understanding from my doctors was that since the AI depletes bone, it creates a favorable environment for tumor growth in the bones especially in high risk spread of breast (and prostate) cancer. I will probably ask in January because at some point, I will be released from my treatment. But, you are correct. They also said it’s given to patients whose cancer has spread to their bones.