Hi, I've had nighttime headaches for at least 10 years now. They happen every night after I go to sleep. I usually wake up at varying times in the middle of the night with a right sided headache only. I think I clench my teeth now, so I got a custom nightguard. It doesn't seem to help, but at least it protects my teeth. I'm 70 years old and recently tried hormone therapy, estrogen, testosterone and progesterone. After a few days, I woke up with no headache!! However, at the recommended dose, I developed the beginnings of diverticulitis - so had to discontinue the hormones. I decided to start back on it again, but very low and slow - hoping that I can still relieve the headaches with a lower dose and not develop any more diverticulitis. I think I should be back up to the dose that relieved the headaches within a month or so. Like I said, low and slow - very frustrating - but hope it works in the long run. Will let you know.