Connect
← Return to COVID vaccines and neuropathy
Discussion
Comment receiving replies
You are correct. There is no spike protein in the vaccine itself. However, by injecting cells with a synthetic mRNA that encodes a viral spike protein, the Covid mRNA vaccines directs human cells to MAKE a viral spike protein. So your own body becomes a sort of spike protein 'factory'. That process should evoke an immune response without a person ever having been exposed to the viral material itself. It may be that, as I said before, those who experience an adverse reaction, are particularly spike sensitive? The vaccine/spike may also induce an autoimmune response in some and perhaps the body continues to produce the spike protein? There is mounting evidence that vaccine-induced long Covid is real (search "Antibodies mimicking the virus may explain long haul COVID-19, rare vaccine side effects"). 13 months after being vaccinated I checked my antibodies. I had no Covid exposure (IgM - neg), but my antibodies were still high (SARS-Cov-2 IgG - 5347 AU/mL ( < 50 ) H). The immediate response to the vaccine I experienced within 15mins (tremors) was, as you say, probably not due to the spike itself (too soon), but more likely a reaction to the polyethylene glycol. The other cascade of long-covid-like symptoms followed within days.
Replies to "You are correct. There is no spike protein in the vaccine itself. However, by injecting cells..."
Connect
I saw that hypothesis out of UCLA. It will be interesting to see if/how it is tested.
However, the article (not a paper; that distinction is important in a scientific journal), does not present evidence. It presents a hypothesis. Not for your benefit (it is clear you have this knowledge) but for the benefit of others, a hypothesis is a statement made to explain observations. For instance, I heard the rooster crow and then the sun came up. Those are observations. Then I say, "so the sun comes up because the rooster crows." That's the hypothesis. Then I test that hypothesis. The rooster goes to live on a farm far, far away where he is happy playing in the fields. No rooster, no crowing, the sun still comes up. So I have falsified the hypothesis because I tested it and the results falsified my statement.
The article in NEJM is just that. It reports observations. Some people who were vaccinated have experienced allergic reactions, myocarditis, and immune-mediated thrombosis and thrombocytopenia. The hypothesis is that these conditions may have been mediated by what is called Ab2 antibodies (antibodies are part of the immune system).
The authors propose a test: It would therefore be prudent to fully characterize all antibody and T-cell responses to the virus and the vaccines, including Ab2 responses over time. Using huACE2 transgenic mice and crossing them with strains that are predisposed to autoimmunity or other human pathologic conditions can also provide important insights.
In other words, no evidence yet. They propose a way to find the evidence.
Food for thought - polyethylene glycol is being tested as a means to fuse axons to treat peripheral nerve and spinal cord injury. https://www.sciencehistory.org/distillations/magazine/chemical-hope