I took neomycin 2/day for 28 days and it is what finally removed my SIBO after fighting it for over 2.5 years. I would do it again in a heartbeat given how bad my quality of life was. No kidney or hearing damage, but of course your experience could always be different. I would ask your doctor/pharmacist for clarification on what the documented rate of hearing/kidney damage is, what steps you should take to minimize it, and what extenuating factors increase or decrease your chances. Only then are you in a position to make "informed consent".