Hi - I recently started experiencing the same problem....but at night. I nebulize 7% saline in the morning and 3% late in the afternoon. I am also on the Big 3 but the coughing at night has really gotten worse and I bring up large amounts of white mucus and then a large chunk of yellow mucus comes up. I use Albuterol before I nebulizer and I also use an Aerobika in the morning with my nebulizer. I recently started Autogenic drainage which is a breathing exercise that helps to bring up the mucus.
I am frustrated and not sleeping for any consecutive amount of time.