Hi Diane - After 16 years of no detectable cancer I’m now 1 year into treatment for BC mets to the bone. My 27/29 started at 2800 (doc said my PET lite up like a Christmas tree) and we’ve gotten it down to 384 with Ibrance/Letrisole ( 8 months) then Afinitor/Faslodex (4 months). Most people here seem to be concerned if they’re above 40 with the 27/29 - so I’m interested to see someone higher. But it’s going up again. My onc doc does a PET scan before deciding if I need to change meds. I have a protein mutation (PIK3CA) that can be targeted with piqray (alpelisib) tablets.