I took letrozole for 5 1/2 months then my oncologist said I could take a break because of extreme side effects. She now wants me to take exemestane to see what side effects I might experience. After 4 1/2 months my trigger thumbs are finally getting better. I'm trying to decide whether to go back on the AIS. I don't really want to put my body through this kind of test. I'm puzzled why the doctors aren't interested in tracking estrogen levels. My primary physician used to be a naturopath before cancer. She tracked my hormone levels because I was taking bioidentical HRT. I think I will have to go to her and pay out of pocket for a blood test to track estrogen levels. It's expensive and medicare won't pay for it. This is being a very difficult decision for me, as well, and I found your post helpful and hopeful! I don't want fear to run my life either. I'm still in the information gathering stage and seeking support. My oncologist has said that if I choose not to take the AIs she can only see me once a year to palpate the scar left by the bilateral mastectomy. Evidently there is no other screening available to track possible recurrance, and then if/when symptoms show up. I'm hoping my PCP will provide some support, as well. My Oncodx score was 11. ILC