Hi Fiona, you mentioned an interest in learning more about available clinical trials for metastatic colon cancer. You can search clinical trials at Mayo Clinic here: https://www.mayo.edu/research/clinical-trials

You might find it easier to call Mayo Clinic Cancer Trials to talk with a coordinator to see if there is a trial that would be specific to your diagnosis.
Cancer-Related Clinical Stuides Questions
Phone: 855-776-0015 (toll-free)
Contact form https://www.mayo.edu/research/forms/cancer-clinical-trials

You mention that your oncologist recommends seeing how it goes with your current chemo regimen first, and if it doesn't get the hoped for results, then search for a clinical trial. That sounds reasonable. Keep them posted on your fatigue and side effects. You want quality too.