Hello, I am new to this group.
I probably already had several light symptoms for more than a year, and problems in my left foot for over 40 years as result of an old accident. However, driving home last week from a seminar in Brussels, Belgium, to my home in the Czech Republic (700 miles spread over two days), I got strong numbness feelings in the outer toes of both feet, and itching under my soles and the front of my lower legs. No pain.
Compared with most here on this forum (and my wife after a light chemo treatment) probably not yet that shocking but it scared me, especially the sudden onset.
My doctor did some test (CRP, strep-test, COVID, blood pressure) but all was in the green. She did not do a blood test but decided to give me a vitamin B complex mega-dose treatment for 14 days to see if that helps: all B vitamins at 100% recommended daily value per tablet, 6 tablets per day (??).
As background, I had a rather intensive work period behind me (running a non-profit with two visitor centers) and had been traveling abroad as well. Coming back from a week-long conference (traveling in cramped airplanes and driving the last bit), I ended up with some severe stomach problems the next night and day (diarrhea, cramp, but no nausea, vomiting, or fever). A day later I started driving 700 miles over two days, then one day seminar, then another two days driving back. As you can imagine, with irregular eating while traveling my stomach has not completely recovered from this ordeal, and my doctor suspected that a viral infection combined with bad food uptake and cramped seating has created or worsened this problem.
Although living here, I am not a Czech and do not really have 100% confidence in the medical rituals here.
Is such a mega-dose treatment normal in such cases? Especially the 1200 ugm B9 per day seems rather a lot.
Additional info: 66 year old, pre-diabetic on 500 mg metformin per day, and light non-allergic asthma (never had an attack, just an initial extreme high FeNO) with minimum maintenance (1x 1 inhalation symbicort in the morning). Had Covid at least twice, probably three times, no serious effects although the attack in January 2021 was also one day stomach problems, this time with a bit nausea and medium fever and after that problems in the ENT domain (normal for me, but these effects were strange). Had both vaccinations (Moderna) and the booster.
Welcome @robomcd, I take a lot of B vitamins also but not the B complex in addition to other supplements that help nerve regeneration (if it's going to happen 🙂). I also only have the numbness and some minor tingling with my neuropathy. I shared my story in another discussion here:
-- Member Neuropathy Journey Stories: What's Yours?: https://connect.mayoclinic.org/comment/310341/
There is another discussion on the numbness only symptoms that you might find helpful:
— Neuropathy: Numbness only, no pain: https://connect.mayoclinic.org/discussion/neuropathy-numbness-only-no-pain/
Sorry I don't have an answer to your question on are mega doses helpful. I'm thinking that it really depends on each person and possibly whether or not they have a vitamin deficiency or absorption problem. There is some information on the supplements that help on the Foundation for Peripheral Neuropathy website here:
-- Complementary and Alternative Treatments:
https://www.foundationforpn.org/wp-content/uploads/2020/08/Complementary-and-Alternative-Treatments-Revised-2020-final.-1.pdf
You mentioned you are on 500 mg metaformin daily. One of the serious side effects of metaformin is nerve damage. That might be a good discussion with your doctor to see if there might be alternatives.
"Can metformin cause nerve damage?
Long-term use of metformin is associated with malabsorption of vitamin B12 (cobalamin [Cbl]) and elevated homocysteine (Hcy) and methylmalonic acid (MMA) levels, which may have deleterious effects on peripheral nerves."
-- Association of Metformin, Elevated Homocysteine, and Methylmalonic Acid Levels and Clinically Worsened Diabetic Peripheral Neuropathy: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797962/
Are you able to discuss the symptoms with your doctor as a possible side effect of metaformin?