I also took 75 mg of venlafaxine time release ..same things as Effexor time release . Horrible side effects trying to stop. I finally thought to myself, since these are time release capsule how could I cut the pill? Impossible. So this worked beautifully for me to get down to the 37.5 mg. I got a small bowl and a very pointy tweezer. ( make sure to have the short end of capsule at the top as you slowly pull apart) At first I removed 15 beads, WHOA! No NO NO I had to remove much less beads. I started by no taking out 2-3 beads, I would do 7 capsules at a time for my weeks supply. NO SIDE EFFECTS!!!!!!! I did this over the course of a few months. Totally worth it in every way no side effects. Now I want to get off the 37.5mg Same thing..today I took 3 beads out of 7 capsules. I know it will be painless. If you decide to do this, make sure to log how much you take out each week. It's not that time consuming and very rewarding. Each week remove 2-3 more beads, you will know if you take out too much., this works !!!! Toward the end it can be a bit tedious but so very worth it. There is about 100 beads in a 37.5mg