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Post prostatectomy: What do rising PSA levels mean?

Prostate Cancer | Last Active: Oct 6, 2023 | Replies (172)

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@jic811

Dr David Thiel at Mayo Florida robotic removal 11/2009 with 3+4 Gleason. Have not been to urologist since back to Mayo 2015. PSA was .01 first 3-4 years and then going up. Went back to Mayo 2015 and PSA .18. Here are test results going forward: 8/15 .22. 6/16 .23. 9/16 .27. 10/16 .26. 3/17 .26. 6/17 .28. 11/17 .31. 3/18 .31. 6/18 .28. 9/18 .32
12/18 .35. 11/19 .5. 12/30 .47 10/21 .72. 5/22 .74. 9/22 .965x
Prostate oncologist at Vanderbilt
Said no concern in may 22 check 6 months and now says no concern and check in 6 months. ??????

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Replies to "Dr David Thiel at Mayo Florida robotic removal 11/2009 with 3+4 Gleason. Have not been to..."

Why does he say not to be concerned . And at what threshold does he recommend radiation?

@jic811, I can see you remain concerned about your rising PSA since your last post last year. I'd ask the same questions as @james1951. Did your oncologist say why he is not concerned? At what threshold would he recommend further treatment? Have you had other diagnostic testing to rule out cancer recurrence?

Is it time to refer back to Mayo Clinic for a second opinion?

I also want to point out the great advice provided by fellow members @dpcarriere and @kujhawk1978 in this related discussion:

- Rising PSA's after treatment - an answer https://connect.mayoclinic.org/discussion/rising-psas-after-treatment-an-answer/

The bottom line:
Everyone is different. It's about the trend line. I encourage eveyone to click the link above.

Hi,
No medical professional here, however, based on what you are stating and what I have learned, is it possible he is considering the rate of your doubling time as a consideration for 'wait and see'.? It appears (if I am reading your scale correctly) your DT is slow and perhaps they do not want to 'overtreat' unnessarily? It may be worth a second opinion however.
D

I ran across a paper, which is not exactly on point, but I think may be useful to some. I tried to include as an attachment, but it was slightly to large a file. The title is:
" Low Detectable PSA after Prostatectomy - watch or treat? " by Koulikov et al.