I've been on daily Big 3 plus Arikayce for the past month. Prior to that, I was on 3 x weekly Big 3 for over 9 months without sputum conversion. I take the Big 3 in the evening at least 2 hours after my last meal with one saltine crack and a few sips of water.

I had no side effects on 3 x weekly meds, and haven't experienced any side effects since switching to daily meds.