I had an adverse/allergic reaction to Plaquenil. I took it for 16 days and my joint symptoms had improved and I was very hopeful for relief as I had JRA diagnosed at age 5. My symptoms have continued my entire life and had a rheumatic nodule removed from bottom of big toe at age 28 but continue to be seronegative and am now 55. My reaction caused me to be hospitalized for 6 days on IV steroids 60 mg with 50 mg Benedryl every 8 hours around the clock. They were afraid it was going to turn into Stevens-Johnson Syndrome. The attached pic was taken after 4 days of treatment.