I am a hyper analytical technologist and force fed myself numerous research papers, pharma white papers, FDA documentation, etc and came to the conclusion that other than the statistics, I wasn't capable of making a qualitative analysis in a field so far outside of my area of expertise. Ultimately, we have had to rely on the oncologist's recommendations with second opinions as needed. The bottom line is that none of the "approved" regimens are successful for all people. Every patient becomes a field study relevant to that patient.

It's not surprising that side effects of folfirinox are severe. So try it without oxalyplaten. There are mutations which platinum drugs are effective against and other times all the platinum provides are bad side effects but no greater tumor reduction than treatment without platinum. My wife had half of her presurgical treatments with platinum and half without. Stopping the platinum didn't reduce the effectiveness. Of course he'll still have to deal with the i-ran-to the-can effects.

Whatever he chooses (and he should choose SOMETHING), get the treatments, track the effects and ask questions. And if you think a change in regimen will be beneficial, push for it. Tell your husband that he's a trial of 1. Appeal to the scientist.