My ID doc is also aggressive when it comes to treating pseudomonas, even when colony counts are low. One of the things that gives me hope is recent and ongoing research about how to make pseudomonas more vulnerable to antibiotics and immune surveillance, by interfering with biofilm formation, efflux pumps, and quorum sensing. Enzymes, herbal meds, pharmaceuticals, and other substances have shown promise, at least in petri dishes. Much more research is needed, including human testing. Numerous entries on Pubmed and other sites. How to safely deliver these substances to the lungs could be a huge challenge.