My husband has been on Orgovyx for a year, with no side effects. Prior to that time, he had 4 monthly degarelix injections.
I see the advantage of Orgovyx as being a GnRH antagonist and fewer deleterious cardiac effects associated with the agonists, like Lupron.
Most of the side effects some men experience are related to the low testosterone, and would be present no matter the method for lowering T.
The other advantage is for those men who might not be on ADT forever. Rapid testosterone response upon discontinuing Orgovyx makes that a more attractive alternative.
Lastly, the convenience of taking a pill at home vs the monthly injections of the only other currently available antagonist made this an attractive option for us.