Hi @isrexpo ,
Sorry to hear your having to go through all that. Had RP about a year ago. I'm on orgovyx. The side effects for me have been fatigue, shrinkage and hot flashes (although I just finished a round of radiation so some of the fatigue may be that), I guess I'll know more in a few weeks. I do seem to have joint pain as well.

Testicles have definitely shrunk, I'm guessing the orgovyx is the culprit there. I can still get erect (with a little more effort as opposed to before). There's shrinkage there as well but again, how much did the surgeon take vs the hormone therapy, my two treatments are so close together it's hard to tell.

"Also does light exercise cause testosterone to rise, which defeats the purpose of the hormone treatment" this is a great question I've asked my Radiation oncologist, he claims that the answer is not enough to matter. He feels that if exercise helps you mitigate the side effects or just helps you deal with them, it's better to do so. I lift 4 days a week and run 8-10 miles a week. Having said that, in lifting you I've had no gains in muscle mass or actual lifting capacity since on the orgovyx, is some of that psychosomatic, possibly.

I really believe for me, the worst side effect is the hot flashes when they happen at night effecting my sleep. It has gotten better (less frequent) over time. (approx 5 mos at this point)

I just had a blood test, before radiation and orgovyx my level had snuck up to .091, now it's back down to .014. My PSMA was negative.
Good Luck !

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