I have taken a course of high dose-to taper off prednisone twice for Nephrotic Syndrome MCD. Both times my hair thinned dramatically and definitely changed texture. I also grew sideburns. Once I am off the prednisone, my hair thickens and goes back to the original texture. My sideburns disappear.
Prednisone has too many side effects to list, but I feel it saved my life. Currently I am taking CellCept for my kidney disease and I don’t believe this drug changes my hair.