Hello, @daisymiq. I am quickly approaching my 1 year "anniversary" (11-4-21) of dermatographia, itching and hives. I began Xolair February 2022. I have my doses scheduled monthly. Reading the side effects of Xolair concerned me. However, after speaking with my PCP of 20+ years I took her advice and began the injections through an allergist. For the first dose, I was required to stay in the office for an hour post injection. I was fine. I was sent home with a script for an Epipen. I have not needed to use it. The wait time post injection decreases monthly. I now leave the office after scheduling my next dose. Does it work? Yes, for about 15-18 days. I can tell when I need my next dose and it takes a few days to get back up to the level of comfort. I no longer have hives, however the dermatographia remains. If I scratch my skin, the redness and slight swelling lasts for 30 minutes. My scalp, feet and ears remain very sensitive. One side effect of the Xolair I have experienced a few times is a stiff neck. It is not every time, but it has happened. I hoped to be done with Xolair after 6 months...I am not ready to stop yet. I also take a 1/2 pill of Zyrtec daily. For everyone else still suffering, hang in there. I remain hopeful one day I will wake up to zero skin issues.