Sue, I started nebbing the 7% saline in Feb 2020 and noticed an immediate thinning of sputum making it easier to get up with my airway clearance. Can't really say it made me feel any better until I stopped taking antibiotics in Oct 2020. Also for anybody interested PulmoSal 7% (pH+) is now available at my pharmacy (Sams Club). I have been using it for a few days and can tell that my airways are less "irritated". For more info check out this post https://connect.mayoclinic.org/discussion/ph-balanced-7-saline/ Bill