Hi, njodctode, "Laughter is the best medicine!" as it was once said by "somebody"!! Lotsa people use methotrexate. I never have to this point, so I don't know a whole lot about it. I know it doesn't work for everyone, but it does help many to get their pred dose down. You probably know much more about it than I do, as you've used it in the past. But you say you had problems, so that would need to be a discussion with your doctor. I think I would have a straight forward conversation with the doctor, saying you'd like another chance with the prednisone doing it the correct way - gradually - and see what kind of headway you make. And then if it doesn't work, the methotrexate might be called for. You need to go to a site called HealthUnlocked.com/pmrgcauk and go totheir FAQ's and look for their tapering plans - several to choose from- and see what works for you. Again, I wish you the best!