My wife isn't a good barometer for judging the effectiveness of digestive drugs. She only has 40% of her pancreas, no spleen and no gall bladder. Her digestive system has been destroyed by 3 years of chemo. Many people report that Creon helps them. Many actually say that they can eat quite well. The problem with Creon is dosing. The doctors really have no idea how to prescribe Creon. My wife has prescriptions for the 12000, 24000 and 36000 sizes and uses whichever she guesses is the right amount for the volume of food and the fat content. It's been all trial and error. For a full meal, usually 3 x 36000 with 1 taken before first bite, 2nd after a few forks and the third closer to finished. The smaller doses are used for snacks. Good luck.