I have posted before that my endo doctor will not use Prolia for me, and people here have asked why. I talked with him today and he said he does use Prolia and it is a good drug. However, he has concerns about the drop-off of protection when you go off, and the resulting potential for fracture. It can be followed by Reclast, sure. He joked that some MD's prescribe it before retirement so they don't have to deal with the end of treatment! He also said that the rise in bone density is consistent and steady over years (unlike Tymlos, which builds the most in the 1st 6 months, then the next 6 months, then starts to level off. Of course Tymlos builds better quality....)