Hello Josey. Yes! The three meds taken for MAC can affect your thyroid medication. You need to talk to your dr about that. I feel badly that you are feeling depressed; I wish I could give you a big hug. Trust me, we have all been there. The more you learn and the treatment beats the mac infection down; you will feel better about things. Please keep reading through old posts from the DISCUSSION board; you will learn an incredible amount about living with mac and bronchiectasis. Like you, I went for 10 years going to 'the best pulmonologists' and none could diagnose me properly. It wasn't until 2013 when I went to Mayo that I got diagnosed, and my exacerbations under control. They were able to get the constant cough I had for 10 yrs to go away. Extreme fatigue comes with MAC as you know. I suffered from that for many years, but have more energy now. I still have my off days where all I do is rest on the sofa. I listen to my body; when it says I need rest, I do. Exercise is key, I walk a mile every day, and probably another mile in my house, (even on my sofa days). I have two dogs that need walking, so not doing it is not an option. Weight loss and muscle wasting can also occur, so it is very important to, at the very least, use stretchy armbands to keep your arms toned. There are leg exercises too that can be done while seated. You can do these while watching television. Now, I have never heard of steroids being a No-No for patients with bronchiectasis. I just came off of a five day run of them for a sciatic nerve problem. I felt like a totally normal, healthy human being on them, I wish I could stay on them, but I know that is not a healthy option. Were you on steroids long term?