Reading this in 2022 -- so many of the posts strike a nerve with me here. Someone said carvedilol turned them into a "stressed-out maniac," and I concur.

I was put on carv on 5/20 by a cardiologist who diagnosed three tachycardia episodes as IST, no other tests, nothing. Put me on the 25 mg 2x a day -- no up titration -- what a mistake. I was a flat pancake. Couldn't function, begged them to reduce the dose -- they said I'd get used to it. Went to ER a few times for low heart rate -- then the panic attacks started a few weeks later. They said it was me, added sertraline and tranquilizers. Heart rate continued to go lower. I lost 20 lbs in 8 weeks, no appetite. One good thing was that I could sleep -- but the dreams were horrible.

Then the depression kicked in and I have been having terrible thoughts -- uncharacteristic -- I'm happy, I love my life -- really dark stuff, like I will never enjoy anything again, desperation, ennui. No thoughts of suicide, but definitely fear that this won't stop and might be better to die. Suffering leg pain, anxiety.

I decided it's the carvedilol and with my GP started tapering the day before yesterday. Now feeling a lot of anxiety, like I want to shake. I hope it goes away soon. I have hope and fingers crossed that when this washes out, I'll get myself back again.

Has anyone else gotten past the side-effects of withdrawal and seen an improvement?