I was forced (very regretfully) to have to discontinue the only antidepressant that ever worked for me - NARDIL, an MAO inhibitor - because of serious side effects. (No, no hypertensive crises - I was diligent about my dietary restrictions).

I was crushed, and tried to continue the Nardil at a reduced dose, but even that was clearly endangering my cardiac health. I had severe pitting edema, especially in my ankles and calves (classic sign of water retention).

When I realized I was bringing on congestive heart failure, I finally relinquished the Nardil (and regained my severe depression 🙁 ).

Not that your problems stem from an MAO inhibitor, but just another example of how medications can cause this edema (and serious systemic dangers)* I'm sure there are other causal medicines.

Sorry if I missed such a reference, but aren't you prescribed a diuretic to reduce your water retention (besides, the obvious requirement of eliminating/reducing salt consumption)?

*I was VERY interested in the report on how amlodipine can cause this leg swelling even though I don't take it! Thanks for the heads up.