I take the Prunelax every evening at 7:30pm, or as near that time as possible, and it produces a result the following morning. I also use psyllium powder, mixed in my cereal or oatmeal. (8 mg) daily. I occasionally use Metamucil crackers also, one or two depending on my diet for the day, making sure I drink a full glass of water with it. The psyllium powder makes my oatmeal a slime and I've come to find it repulsive. It inflates the volume of the oatmeal, so I've divided it in half because I just couldn't "stomach" it anymore. On those days, I supplement with the Metamucil cracker, in addition to the oatmeal. It works for me and I don't feel like I'm going to vomit with the slimy oatmeal. I've been doing this for quite a few years. The cereal is much easier and palatable for me but I know some people have difficulty with milk. But as we discussed earlier, everyone is different and we all need to find what works for us as individuals. Medicine practices have changed. And my husband, who is a retired clinical pharmacist, is the first to make that statement. He worked in a hospital for over 30 years. A clinical pharmacist is much different than a retail pharmacist at a drug store. He dealt with life and death situations. He has commented numerous times that the treatment now has turned into a "herd treatment" vs focusing on the individual. So we have to be our own best advocate and not give up! Jacque