I started letrozole November one of 2021. At first, I experienced gosh awful hot flashes, hair loss, extremely dry skin, and depression. However, they have pretty much subsided now. My system has always been hypo glycemic (low blood sugar); however I’ve now been diagnosed as prediabetic. The good news is, for me, my last A1c test showed that my system has adjusted back down to just under the prediabetic numbers. My hair seems to have stopped falling out; my skin is becoming more moist. My points: it seems that my body is acclimating to the Letrozole over time and the side effects are calming down for me. My oncologist and I have discussed this. My choice is to hang in there and see where this all goes for me. By the way, I agree with the fact that this 80 year old body had very little estrogen in it to begin with. L O L