I was on Verzenio for 18 mos along with Arimidex for my first drugs when I was identified as being MBC. I did not do any chemo or radiation after my double mastectomy but instead did those meds. I had diarrhea/urgent need to go for about 1 week and then very infrequently over the remaining months. I pivoted to a much healthier diet with more fruits and veggies, blander food and protein shakes. You will be given Imodium to counteract the diarrhea but i didn't like the swing between the 2 meds. I will tell you also that my hair thinned out and my nails became more brittle - could be either of my 2 meds or both together. I started taking Hair, Skin and Nail gummies which is a lot of biotin, and I believed that helped...even through my later chemo. My docs were very pleased that i had a great 18 mos and I agreed. I went about my normal busy routine. While my docs and I hopeful were hopeful that i would be on it longer, my MBC is weird because it was initially in my skin which is our largest organ. The Verzenip completely took care of it there and it did not come back there when my MBC went to other areas. But the good news is there are other great drugs we pivoted to after a bit of a bumpy road and now I am back in remission again. They told me to think of my cancer as a chronic condition. Three years later I am still busy and I keep moving. Good luck!!