Six months after my first Lupron injection my PSA was undetectable. I guess that's good news in the war on cancer. The side effects in my case have been hell! My biggest problem has been taking my bad knees/hands and made them even worse. I calculate how to minimize my steps before I do anything. Extreme fatigue is another big issue. I just have no energy. I'm not getting anything done and I've given up activities I enjoy. Mild cognitive degeneration is becoming noticable to me. Not a big deal but I find myself occasionally looking for the right word or just plain being "a little foggy." Using the toilet is messy because, well, short barreled guns are hard to aim. While not a real hindrance to quality of life, I'm still having a hard time accepting breasts.
Surgery was not an option so Lupron/radiation was the only way to go. IF other treatments are available I'd recommend against Lupron, yet if that's the best for you then that's what you do. Last month I took my second injection.