There is a Mayo Clinic article about Alosetron. But this site won't let me post the URL I am not a big drug taker. I even use over the counter meds in moderation.

I have lived with IBS-D for 22 years. Some bouts are more severe than others. My triggers are stress, anxiety, fatty foods, popcorn, corn, cauliflower, even beans and I watch how much daily wheat I eat. I keep Barilla gluten free pasta in the house - which I have found to be the best in texture and taste. I love to bake, but give away most of what I make (except for a small piece for me). Otherwise I may eat too much and have a bout. I tend to be a home body, but will go out with friends, I just make sure I haven't eaten anything that might set me off. The longer I have this, the easier it has become to manage or should I say tolerate. Sometimes though I have a bout and can't figure out what the heck triggered it. Go figure.