fdixon, I used the inhaled toby for many years and it would make me feel worse for the first three weeks. Then, by the end of week four, I would see much improvement and the cough would cease. I was on the toby every other month, and I remember saying to myself whenever I would first start the treatment; "It is always worse before it gets better." I feel like the increase in color that you see in your sputem may be due to the toby bringing up gunk from way down within your airways. I also want to mention that when I first went on the toby; I lost my voice for weeks. After several months of toby use, all side affects went away and I could nebulize the med with ease.