My onco and I are working very closely together. She actually has an interest in the reactions of women to these drugs. While we researched we found that it is only a 5% increase in chance for a better result. She is more interested in why I had this reaction. We have found through my geneology that arthritis in my genes, mother, sisters, aunt, father, uncles, etc. is brought to the forefront when taking these drugs, and only heightens these side effects in the drugs. We also found that the fillers used can have a dramatic affect, and if not tolerated, should consider a more pure drug, unfortunately not covered by most insurances. I see her every 6 months, along with my doctor. There are many studies out there, and I am fortunate to have an oncologist that realizes how strong these drugs can affect the body, while most only follow the studies in place and have little knowledge of other alternatives. The cancer may be at bay for a few more years, but the issues these drugs cause can create problems that make living with a decent quality of life quite difficult. I stand by my statement and I am very happy for you and others that you can tolerate these side effects. Good for you. Not for all.