My neurologist suggested ALA for my neuropathy which was very painful in both legs, and especially my big toe. I started with Jarrow and in 3 weeks had some relief. I then switched to Pure Encapsulations which is much more expensive but has no fillers and got much better relief. I was up to 2400 units per day to quiet that big toe. Then during Covid I lost 50 pounds and was getting stomach aches from such a large dose. Reduced amount to 1200 units and all is fine. Suggest use good brand like Thorne or Pure Encapsulations. ALA is a prescription drug in Germany and is given intravenously in large doses. Many doctors in this country unfortunately do not know about it. (PS - also good for skin)