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@windyshores

I did a Breast Cancer Index and a Prosigna Assay test at the 5 year point of AI therapy. Both tests considered a risk of recurrence >5% to be high. Unfortunately the risk of recurrence with hormonal cancers continues to go up. (If hormone-negative cancers make it 5 years, risk tends to go down, I have read).

It is counterintuitive but the longer we go without recurrence, the higher our risk.

I had an Oncotype of 8 and risk was 6% with meds, 12% without. I also looked at pathology which didn't match the Oncotype in a lot of ways: grade 3, lymphovascular invasion, highish ki67% and borderline HER2.

I already had osteoporosis when I started Femara. I did not medicate for bones for the entire 5 years of AI therapy. (My endo did not want to do Reclast or Prolia due to some other health issues and I had not tolerated Forteo).
My bone loss the first year was similar to the drop at menopause, then it kind of stabilized for the next 4 years on meds. I ended up on Tymlos after cancer meds (and after fracture, but the fracture was due to a very wise, unusual movement.)

Breast Cancer Index said I did not need meds for years 5-10. They could not tell me whether I had actually needed them for years 1-5. I felt so safe on the meds and had few side effects. I actually wanted to continue!

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Replies to "I did a Breast Cancer Index and a Prosigna Assay test at the 5 year point..."

@windyshores Your statement in your post “ It is counterintuitive but the longer we go without recurrence, the higher our risk.”
I do not understand. Please explain

I have almost exact story. I completely agree with you… I was on tamoxifen 5 years and in my 4 th year of an AI, nervous to go off..
No bad side effect, thank God!