I am not too familiar with 23 & Me, but when you look down through your list of genes, you can easily spot some of the troubles. First thing, sign into OMIM.org. Then enter one or two of your symptoms in OMIM.org, It should give you a group of genes/ syndromes to investigate further. If you have ANY of the genes it suggests, and 23&me shows you have them, you have your first clue. Just remember that 23&me checks about 0.1% of your total genome, and your search has begun. One of my genes is CF, (cystic fibrosis) Very common. But just start looking, and you will find something. oldkarl